Bone Abstracts

Osteoporosis is the commonest worldwide age-related bone disease. It is clinically symptomless until the first fracture happens. Circulating microRNAs can be used as novel biomarkers to assess health status and progression of complex diseases. A recent review highlighted the involvement of microRNAs in the control of bone formation and remodeling. Most of these studies have been done on animal models, but few on human blood samples.This research aims to ...

Osteoporosis is a metabolic disorder of the bones that shows increased incidence in post-menopausal women where estrogen deficiency plays a significant role in its development. Estrogen also decreases endoplasmic reticulum stress by decreasing the expression of ER stress markers.Using a combination of subtractive cDNA libraries and microarray analysis, a panel of estrogen dependent mRNAs/proteins was identified, including transcription factor, XBP1/1S; p...